ADHESION MOLECULES AND DIFFERENTIATION SYNDROME: PHENOTYPIC AND FUNCTIONAL ANALYSIS OF THE EFFECT OF ATRA, AS2O3, PHENYLBUTYRATE, AND G-CSF IN ACUTE PROMYELOCYTIC LEUKEMIA

Background and Objectives Differentiation Syndrome (DS) is a treatment complication which can occur in patients treated with acute promyelocytic leukemia (APL) with all transretinoic acid (ATRA) or As2O3, and is characterized by enhanced leukocyte transmigration.As2O3, Phenylbutyrate (PB) and G-CSF are known to potentiate ATRA effects.Our aim was t

Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders, which brings enormous burdens to the families of patients and society.However, due to the lack of representation of variance for diseases and the absence of biomarkers for diagnosis, the early detection and intervention of ASD are remarkably challenging.In this study, we pro